Multicrossover Randomized Controlled Trial Designs in Alzheimer Disease
نویسندگان
چکیده
منابع مشابه
Effects of the Finnish Alzheimer disease exercise trial (FINALEX): a randomized controlled trial.
IMPORTANCE Few rigorous clinical trials have investigated the effectiveness of exercise on the physical functioning of patients with Alzheimer disease (AD). OBJECTIVES To investigate the effects of intense and long-term exercise on the physical functioning and mobility of home-dwelling patients with AD and to explore its effects on the use and costs of health and social services. DESIGN A r...
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The continuous increase in elderly and oldest-old population, and subsequent rise in prevalence of chronic neurological diseases like Alzheimer's disease (AD) and Parkinson's disease (PD), are a major challenge for healthcare systems. These two conditions are the most prevalent neurodegenerative diseases in older persons and physicians should engage treatment for these patients. In this field, ...
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Background: Different types of corticosteroids with different characteristics, such as hydrocortisone and dexamethasone, have been used in treatment of exacerbated chronic obstructive pulmonary disease but drug of choice unclear. The main goal of present study was to compare the efficacy of hydrocortisone and dexamethasone on clinical symptoms, peak expiratory flow, oxidative stress factors and...
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OBJECTIVE To evaluate the efficacy of donepezil in patients with early-stage Alzheimer disease. DESIGN Multicenter, randomized, double-blind, 24-week, placebo-controlled study that enrolled patients with early-stage Alzheimer disease. Patients were randomized in an approximately 2:1 ratio to donepezil, 5 mg/d, for the first 6 weeks, with a forced escalation to 10 mg/d thereafter (n = 96), or ...
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ژورنال
عنوان ژورنال: Annals of Neurology
سال: 2018
ISSN: 0364-5134
DOI: 10.1002/ana.25280